How to Choose Right Syringe Filters and Filter Membranes

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Wickr: puresteroid

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Email: selina@ycgmp.com

The texture of syringe filters include Nylon, PVDF, PTFE, MCE, CA, Glass Fiber, PP, PES.

When choosing the texture of syringe filters, we need to consider pore diameter, chemical resistance( if can resist all carrier oils and solvents), oil-based or water-based solution, and etc.

Here are the pore diameter of common syringe filters.

Pore diameter:
Nylon, PVDF, PTFE, MCE, CA, PP, PES: 0.22um, 0.45um
Glass Fiber: 0.7um, 1.2um

Here are some common questions we enounter when choosing proper syringe filters?

1. Is it necessary to have a 0.22 um to have a sterile solution or the 0.45 um gives acceptable results concerning the dangers of bacteria ?

2. What is the average filtering time per 100ml oil-based injections and water-based injections? What carrier oil you use?

3. Warming your injection will make filtering much easier. What is the filtering time difference between warmed and unwarmed oil?

4. Which membrane are the best for a steroid based solution? Oil-based and water-based.

Here is the chemical resistance chart of Whatman syringe filters/filter membranes.

Nylon PVDF PTFE MCE CA Glass Fiber PP PES
Benzyl Alcohol LR R R R LR R R NR

R=Resistant
LR=Limited Resistance
NR=Not Resistant

I would like to answer the above questions with my shallow expertise.

1. 0.22 um is used for sterilizing-grade filtration. Literally speaking, getting rid of bacterials. 

0.45um is used for clarification filtration and pre-filtration. Always stick to
0.22 um though more time-consuming. I want to correct my words in the past posts.
4. Just considering the pore diameter, Glass Fiber is out of the game. Then comes to chemical resistance, Nylone, CA, and PES are out of the game too. So the rest
options might be good for use: PVDF, PTFE, MCE, PP. But deeper consideration is: would these syringe filters not be eaten by other solvents(like BB, EO, guaiacol,
PS80), even carrier oils? As far as I know, sesame oil eats PES.

0.22 um of PVDF, PTFE, MCE, PP are good for use. But it is a open proposition.

Nylon: Nylon
PVDF: Polyvinylidene Fluoride
PTFE: Polyfluortetraethylene
MCE: Mixed Cellulose Ester
CA: Acetate Cellulose
Glass Fiber: Glass Fiber
PP: Polypropylene
PES: Polyether Sulfone

How to Filter Semi-finished Steroid Oil

What Steroid oil We Serve

1.Our Semi-finished Steroid Oil already cooked well, just need to be filtered before using.

2.We only use medical grade solvents such as BA, BB, GSO, EO, Guaiacol and so on to cook our premixed oils, high quality can be 100% guaranteed.
If you have special requirements about the solvents or conversation, pls tell me, our lab will do their best to meet your requirements

3.Buy premixed injections from us directly can save you a lot of money, it’s much cheaper than 10ml finished steroids, and more convenient than raw powders.If you are a retailer, then it is your time to think about opening your own brand, everything needed for a starter(bottles, labels, crimper, filter) would be offered here . 

Whatsapp:+8618872220826

Skype:selina@ycgmp.com

email:selina@ycgmp.com

Why We Do Not Serve Finished Steroid Oil

To ensure safe delivery to your country, we use the discreet package, which can not make sure the sterilize environment. What’s more, this is a great chance for you to make your business also. 

How to Filter Semi-finished Steroid Oil with syringe filter

step 1:You'd better draw a small amount of air (about 1ml) into the syringe before filling with steroid solution. This air is used to purge the filter at the end ensuring the minimum sample is left in the filter.since the quanity is limited and worthwile 

step 2:Load the steroid solution into the syringe 

step 3:Attach the filter safely with a twisting motion, fix it firmly but do not over-tighten. 

step 4:Hold the assembled syringe and filter vertically to wet the membrane evenly. This prevents air blocks and promotes high flow rates as the liquid is spread evenly over the membrane surface. The actual physical design of the syringe filter will have a big bearing on the possible flow-rate through the filter. 

step 5:Press the syringe plunger gently to push steroid through the filter. If possible, discard the first 0.25-0.5ml of sample because if there is any contamination present, it is likely to be higher in those first few microlitres of sample. If the back pressure ever increases significantly, change the filter as it may have plugged. Avoid pressing excessively as this could cause the filter housing to burst. 

step 6: Push the air through the filter to purge the housing and recover the maximum amount of steroid solution.