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Tibolone

Synonyms: TIBOLONE; LIVIELLA; LIVIAL
CAS: 5630-53-5
EINECS: 227-069-1
Assay: 99% min.
Packing: 1kg/foil bag.
Delivery: Express courier.
MF: C21H28O2
MW: 312.45
MS:

Character: White powder.
MP: 169.
Usage: pharmaceutical material, Steroid hormone, Anabolin. A synthetic steroid with weak estrogenic, androgenic and progestogenic activity. A pharamceutical used in the treatment of menopausal syndrome.
Applications:

Tibolone is a synthetic hormone-type drug which is used mainly for hormone replacement therapy in post-menopausal women. It is a synthetic steroid that has the same activity as the female sex hormones estrogen and progesterone and the androgen testosterone. Tibolone helps restore hormonal balance in the body.

Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for the treatment of osteoporosis.Three major metabolites of tibolone are responsible for its tissue selective mechanism of action. Conversion into 3α- and 3β-hydroxy-tibolone results in estrogenic effects in brain, vagina, and bone.

The isomer has progestrogenic and androgenic effects and does not cause estrogenic stimulation in the endometrium.A two-year longitudinal study indicates that low doses (1.25-2.5 mg) of tibolone effectively relieve climacteric symptoms and prevent loss of bone mass in early postmenopausal women.

Tibolone COA