Safe Shipping Pain killer Tetracaine Hydrochloride Local Anesthetic Tetracaine HCl selina@ycgmp.com

Tetracaine Hcl Details:

CAS NO.:	136-47-0
Alias:	Tetracaine hydrochloride ,2-Dimethylaminoethyl 4-n-butylaminobenzoate hydrochloride; 4-(Butylamino)benzoic acid 2-(dimethylamino)ethyl ester hydrochloride CAS NO.:136-47-0
EINECS:	205-248-5
MF:	C15H25ClN2O2
MW:	300.82
Melting point:	149°C
Assay:	99%
Grade:	Pharmaceutical Grade
Appearance:	White Crystal Powder
Usage:	Local anesthetic;Mainly used in mucosa anesthetic.The function is stronger than Procaine and Lidocaine. Tetracaine HCl is a potent local anaesthetic and a channel function allosteric inhibitor.
Storage:	Closed, confined and shading preservation
Shipment Way:	EMS, HK Post, DHL, TNT, UPS, FedEx, Aramex

Tetracaine Hcl DescrptionTetracaine HCl is synthesized from 4-butylaminobenzoic acid. The ethyl ester is formed through an acid-catalyzed esterification reaction. Base-catalyzed transesterification is achieved by boiling the ethyl ester of 4-butylaminobenzoic acid with excess 2-dimethylaminoethanol in the presence of a small amount of sodium ethoxide.

Tetracaine, also known as amethocaine, is a local anesthetic used to numb the eyes, nose, or throat.It may also be used before starting an intravenous to decrease pain from the procedure.Typically it is applied as a liquid to the area. Onset of effects when used in the eyes is within 30 seconds and last for less than 15 minutes.Tetracaine Hcl Applications :

1) Tetracaine Hcl For block anesthesia and epidural anesthesia.
2) Tetracaine Hcl used for ventricular arrhythmias caused by myocardial infarction, digitalism, glucantime poisoning, surgery and so on. Such as ventricular tachycardia, frequent ventricular premature beat, ventricular fibrillation.
3) Tetracaine Hcl As painkillers of injection in the medicament.
4) Tetracaine Hcl used in suppository and ointment preparation,

5) Tetracaine Hcl has been used in spinal anesthesia.In biomedical research, tetracaine is used to alter the Function of calcium release channels (ryanodine receptors) that control the release of calcium from
Intracellular stores.

6) Tetracaine is an allosteric blocker of channel function.At low concentrations, Tetracaine causes an initial inhibition of spontaneous calcium release events, while at high Concentrations, tetracaine blocks release completely.

Tetracaine Hcl Specification

Appearance	White crystalline powder
Assay(*)	98~101.0%	100.4%
Identification	A.By UV, To match with working standard	Complies
	B: Dissolve 100 mg in 10 mL of water, and add 1 mL of potassium thiocyanate solution (1 in 4): a crystalline precipitate is formed. Recrystallize the precipitate from water, and dry at 80 for 2 hours: it melts between 130 and 132 .	Complies
	C. A solution of 100 mg in 5 mL of water meets the requirements of the Tests for Chloride	Complies
PH Chromatographic purity Clarity	4.5~6.5	5.9
	Conform to standard	Complies
	Solution should be clear	Complies
Related Substances	Not more than the reference solution (0.05%)	Complies
Heavy metals	≤10ppm	<10ppm
Loss on drying	<0.5%	0.21%
Resiue on ignition	≤0.1%	0.05%
Melting range	145~150°C	146~149°C

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