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显示标签为“hormone pepide”的博文。显示所有博文
显示标签为“hormone pepide”的博文。显示所有博文

2017年2月4日星期六

Safely Pass Customs Tb500 Thymosin Beta for Body Building Whatsapp:+8618872220826


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Product Name Thymosin β4 Acetate 
TB-4,Thymosin Beta 4
Cas No. 77591-33-4
Molecular Formula C212H350N56O78S
Molecular Weight 4963.49
Purity (HPLC) 95%min.
Appearance White powder
Single Impurity (HPLC) 2.0%max
Amino Acid Composition ±10% of theoretical
Peptide Content (N%) ≥80.0% 
Water Content(Karl Fischer) ≤5.0%
Acetate Content (HPIC) ≤15.0%
MS(ESI) Consistent
Mass Balance 95.0~105.0%

Descrption

TB-500 is an injectable peptide drug which can be used to promote healing, enhance range of motion in cases of injury, or reduce pain in case of injury by reducing inflammation. As yet its human use has been relatively uncommon and limited to individuals who like to experiment. Use in race horses has been more widespread, though it’s not a prescription veterinary drug.

While TB-500 can be remarkably effective administered alone, at least some persons will experience better results with TB-500 taken together with GH than with TB-500 alone.

Alternately, compared to using TB-500 alone, healing effect can be improved by combining TB-500 with a GHRP (such as GHRP-2, GHRP-6, ipamorelin, or hexarelin), or a GHRP / Mod GRF stack.

Effects of TB-500 Demonstrated In Recent Studies

Recent laboratory research and clinical studies conducted using TB-500 (Thymosin Beta 4) have shown that it may promote the following:

• Endothelial (blood vessels) cell differentiation
• Angiogenesis (growth of new blood cells from pre-existing vessels) in dermal tissues
• Keratinocyte migration
• Collagen deposition
• Decreases inflammation of tissue in joints
• Increase muscle growth with huge increases in endurance and strength noted
• Relaxed muscle spasm and improved muscle tone
• Increase the exchange of substance between cells
• Encourage tissue repair
• Stretches connective tissue and helps maintain flexibility
• Prevents the formations of adhesions and fibrous bands in muscles, tendons and ligaments.

TB-500 Storage temperatures:

Before reconstitution (lyophilized / freeze dried powder):
refrigerated between 2 - 8 degrees celsius (36 - 46 Fahrenheit) it's good for 24 months
at room temperature (up to 37 degrees Celsius or 98.6 Fahrenheit) it's good for over 90 days
up to 45 degrees Celsius or 113 Fahrenheit it's good for about a week

TB-500 dosage and cycle duration:

Dosage depends on the purpose and severity of the injury / damage you are treating. People generally use between 4 to 8 mg of TB500 per week during the initial (loading) period of 4 to 6 weeks. Afterwards some opt to maintain the effects with a low 2 to 6 mg dose once every 2 weeks. The effects of TB-500 wear off within 2 - 3 weeks of injection.

1.TB-500 loading phase:

liquid TB-500 should be refrigerated between 2 - 8 degrees celsius (36 - 46 Fahrenheit) at all times. Do not freeze it.
reconstituted TB-500 should be used within 8 days
duration: between 4 - 6 weeks
dosage: between 4 - 8 mg of TB-500 per week
frequency of injection:2 mg per injection, between 2 - 4 times per week (depending on the total weekly dosage)

2.TB-500 maintainance phase:
duration: as long as needed
dosage: between 2 - 6 mg of TB-500 per 2 weeks
frequency of injection:2 mg per injection, between 2 - 3 times per 2 weeks (depending on the total bi-weekly dosage)

Fat Loss Human Growth Hormone Peptide HGH 176-191 Fragment 2mg per vial selina@ycgmp.com

Quick Detail : 

GH fragment 176-191
Synonyms: Fragment 177-191, AOD-9604
MF: C78H123N23O23S2
MW: 1815.08152
CAS  221231-10-3
Appearance: White Powder
Purity: 98%
Grade: Pharmaceutical Grade
Storage: Lyophilized HGH FRAG 176-191 although stable at room temperature for 3 weeks, should be
stored desiccated below -18°C. Upon reconstitution FST should be stored at 4°C between 2-7 days and for future use below -18°C.
Usage: AOD9604 actually acts on the reduction of excessive adipose tissues such as 
increase in muscle mass, and enhances the lipid content of the body.


Description :

Fragment (176-191) is a fat-loss peptide derived from the GH molecule, which directly initiates lipolysis and inhibits lipogenesis, but in order to better understand this peptide, it is imperative to have at least a rudimentary understanding of its parent hormone .

GH is a polypeptide which contains an amino acid sequence that is 191 amino acids in length. Frag (176-191) was developed by isolating and modifying the specific portion of the GH molecule responsible for the hormone's lipolytic and anti-lipogenic effects.

The portion of the molecule responsible for these effects is amino acids 176-191. In every sense, Frag should primarily be considered a fat loss peptide which performs these functions through the same pathways as traditional GH, but without exposing the user to the potentially undesirable side effects which may present themselves during GH administration.

Application:
fragment 176-191 is an analog of the growth hormone-releasing factor (GRF) which signals the effects of hormone. It is a 15-mer peptide residue of the C-terminus of  to which tyrosine is added at the N-terminal end.

This synthetically produced hormone is very common to weightlifters and bodybuilders because of a number of physical benefits. Studies claimed that it actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body.
 
The effects and results of FRAG 176 191 peptide
increased muscle mass
Increased strength and endurance
reduced body fat
Increased growth of bone tissue
Liver secretion of -1, which burn body fat and increase muscle
Anti-aging peptide

Dosage and Usage

HGH Frag is like all of the other peptides we have covered and come as a delicate lyophilized powder that should be kept out of the light and in a cool dry place. Reconstitution is done with bacteriostatic water or sodium chloride meant for injection. In order to reap the benefits of HGH Frag, users will need to dose around 500mcgs per day. This can be done by dosing 250mcgs in the morning pre-workout, and 250mcgs before lunch or 250mcgs before bed. Users will also want to take note of the timing of injections and their diet at that time. It is optimal to inject HGH Frag 176-191 on an empty stomach or with just protein in the stomach. Like other peptides, HGH Frag has been noted to not work as effectively in the presence of carbohydrates and sugars.


Dosage (Men)
2-6iu or (500-1000 mcg) per day

Dosage (Women)
2-6iu or (500-1000 mcg) per day

Side Effects

The side effects most commonly associated with HGH Frag 176-191 are few but can include: redness or soreness at the site of injection, and excessive sleepiness or lethargic feeling. Other than that, the positive side effects are many. HGH Frag 176-191 destroys fat, promotes lean body mass, does not affect glucose levels, helps to strengthen bones, can improve sleep patterns for many and helps protein synthesis.





2017年1月10日星期二

Body Building Peptide Skin Tanning Steroid Melanotan II selina@ycgmp.com


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Name:Melanotan II
CAS:121062-08-6
Molecular Formula:C50H69N15O9
Synonyms:L-Lysinamide
Appearance:solid
Molecular Weight:1024.17796

How it works?

This peptide is a designed to stimulate the body's tanning response with minimal exposure to sunlight. This can be a wonderful way for those with fair to very fair skin to get tanned without having to spend weeks in the sun and going through the burn and heal process.
By using MT2, users experience quicker tanning and and faster healing to damaged skin cells than would otherwise be possible. Because of this, it is especially suited to those who's skin is pale; those who are at greatest risk of developing skin cancer.

How to use Melanotan II for tanning

Melanotan II is typically provided in vials containing 10 mg of lyophilized (freeze-dried) powder. The vials are reconstituted with a convenient amount of bacteriostatic or sterile water, added to the vial by syringe. An example convenient amount of water is 2.5 mL. When this amount of water is used, the resulting solution contains 4 mg of MT-II per mL. If for example wishing to take a dose of 1 mg, a volume of 0.25 mL, or "25 IU" as marked on an insulin syringe, would be taken by injection. Injection may be subcutaneous, intramuscular, or intravenous, according to personal preference.

Injection typically is only once per day, but where a person is first trying the drug and judging tolerance, injection may be divided into two smaller amounts per day.
Typical dosage range is 0.5 to 2.0 mg/day, with a preferred range of 0.5 to 1.0 mg/day. However, it's best to first assess tolerance with lower dosing of 0.25 mg at a time.

After reconstitution, a Melanotan II vial should preferably be consumed entirely within 30 days. Prior to reconstitution, MT-II should be stored in the refrigerator or freezer, but it's acceptable for it to be shipped without refrigeration.

Melanotan II's effect is fairly long-lasting. It can even be the case that it takes a year or more for a cycle's effect to largely disappear. Use of maintenance cycles can maintain effect indefinitely. As a rule of thumb, maintenance typically requires about 2 to 3 times as much MT-II per year as was needed for the first cycle. This can be taken either as a total of 2 to 3 cycles per year done in the same way as the initial cycle, or any more frequent dosing pattern providing this total amount of MT-II per year.

10mg/Vail Hormone Peptides Bremelanotide PT-141 for Sex Enhancement selina@ycgmp.com


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Unit Size:  10 mg/vial
Unit Quantity : 1 Vial
CAS NO.:  189691-06-3
Synonyms Brmelanotice; BREMELANOTIDE PT141; BreMelanotide Acetate
Molecular Formula C50H68N14O10
Molecular Weight : 1025.16
Sequence :  Ac-Nle-cyclo(Asp-His-D-Phe-Arg-Trp-Lys-OH)
Appearance : White Powder
Purity : 99.53%
Identity (ESI-MS): 1025.16±1.0
Source: Chemical Synthesis

PT-141 Application:

PT-141 or Bremelanotide is the generic term for a peptide being studied for its possible use in helping to improve sexual dysfunction in both men (erectile dysfunction or impotence) and women (sexual arousal disorder). PT-141 has a similar structure to Melanotan-II and is a synthetic analogue of alpha-Melanocyte stimulating hormone (α-MSH). Alpha-MSH is an endogenous peptide that has potential influence over lipid metabolism, appetite, and sexual libido. PT-141 is a potential remedy for the treatment of sexual dysfunction and studies have shown that PT-141 does not act on the vascular system like former compounds, but allegedly works by activating melanocortin receptors in the brain, therefore helping increase ones sexual stimulation.

PT-141 Usage:

PT-141 functions by activating the melanocortin receptor and MC4R namely. Bremelanotide originally was tested for nasal spray delivery but was discontinued after concerns about side effects. Bremelanotide PT141, as Melanotan II, may cause spontaneous arousal enhancing effect. Unlike other supplements, PT-141 results do not act on the vascular body, but directly increases desires through the nervous system.

PT-141 is a melanocortin based peptide that has shown effectiveness in clinical studies on both male and female rats. Male rats have shown erectile response with doses as low as 1-2 mgs whereas most female rats have shown positive results with higher doses around 2-3 mgs. While the dosage requirements tend to be higher for female rats, the observable results in female rats tend to be stronger.


Cjc-1295 Peptide Human Growth Steroid Cjc-1295 Without Dac for Muscle Enhance selina@ycgmp.com


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Synonyms: CJC-1295 without DAC, CJC 1295 no DAC,
 Neorelin, Modified Sermorelin
CAS NO.: 863288-34-0
Molecular Formula: C152H252N44O42
Molecular weight: 3367.2
Molar Mass: 3368.7
Peptide purity: > 98.0%
Appearance: White lyophilized powder
Related substance: Total Impurities (%) ≤ 2.0%
Acetate content: ≤ 15.0%
Bacterial Endotoxins: ≤5 IU/mg
Sequence: Tyr-d-ALA-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2
Source: Chemical Synthesis
Reconstitution: To follow best practice guidelines for reconstituting CJC-1295 without DAC, reconstitute in sterile, bacteriostatic, distilled water, with light sonication if necessary.
Shelf life: One year from dispatch.


Storage for CJC-1295 without DAC


Lyophilized MOD GRF 1-29 is stable at room temperature for 90 days, however it should be stored in a freezer below -8°C for any extended period of time. After reconstitution, may be stored for a maximum of 14 days in a refrigerator at 2°C - 8°C. Store vials in an upright position. Store MOD GRF-129 refrigerated between temperatures 2°C - 8°C. Keep in the outer carton in order to protect from light. For one month can be stored at room temperature.
CJC-1295 without DAC usage

Modified GRF 1-29 is also known as Mod GRF 1-29, but even more commonly known as CJC-1295 without DAC. It is a protein that is 29 amino acids long and it is a GHRH analogue. CJC-1295 without DAC acts on receptors at the pituitary gland to stimulate the release of Human Growth Hormone.

CJC-1295 without DAC could be referred to more properly as a second generation derivative of GHRH. GHRH is modified to create what is known as Releasing Factor (GRF) 1-29, also known as Sermorelin. GRF 1-29 is then further modified to create Mod GRF 1-29 which is CJC-1295 without DAC.

CJC-1295 without DAC Dosage


Mod GRF 1-29 is typically provided in vials containing 2 mg of lyophylized powder, though the amount can vary. The contents should be reconstituted by adding a convenient amount of sterile or bacteriostatic water. If for example 2 mL is chosen and the dosing of the vial is 2 mg, the resulting solution then has a concentration of 1 mg/mL, or 1000 mcg/mL.

At time of dosing, an insulin syringe is used to draw and then inject the desired amount. In the above example, a 100 mcg dose would require a volume of 0.10 mL, or "10 IU" as marked on an insulin syringe.
Injection may be subcutaneous, intramuscular, or intravenous, according to personal preference. If desired, peptide solutions from other vials, such as a vial of a GHRP product, may also be drawn into the same syringe. This reduces the total number of injections required.

I ordinarily recommend a dosage of 100 mcg Mod GRF at a time, simultaneous with injection of a GHRP. For maximum effect, dosing is preferably three times per day at times of low blood sugar, for example about 30 minutes before a meal, but where use is ongoing, a common use is once per day prior to sleep.

Cjc-1295 Peptide Human Growth Steroid Cjc-1295 with Dac for Muscle Enhance selina@ycgmp.com



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Sequence Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Maleimidopropionyl)-NH2

Molecular Formula C165H271N47O46
Molecular Weight 3649.30
Purity (HPLC) 98.0%
Appearance White powder
Single Impurity(HPLC) 1.0%
Amino Acid Composition 10% of theoretical
Peptide Content(N%) 80%(by %N)
Water Content(Karl Fischer) 6.0%
Acetate Content(HPIC) 15.0%
MS(ESI)  
Mass Balance 95.0~105.0%


The DAC technology in the CJC-1295 enables the compound to bind itself covalently with any circulating albumin, after it has been administered through a subcutaneous injection. However, the reason why the half-life could be extended from a few minutes to several days is more profound. The reactive group in the CJC-1295 binds to a peptide through bioconjugation. The peptide then finds a neucleophilic unit within the blood and reacts with it in order to create a firmer bond.

When using any GHRH, it should always be remembered that positive results cannot be achieved overnight. These compounds act steadily over time, and the best results can be achieved slowly, and with a nutritious diet and a proper exercise regime. Also, these peptides are not sex-specific, so they do not have any androgenic effects. They can be used by women in the same dosages that men do.

How to Use
 

Research study participants for  often cycle doses 2-3 times per day (ex: before breakfast, before bed, and after exertion) for a period up to several weeks. These cycles, or pulses are meant to closely mimic natural secretion of GH. For CJC 1295, dosing is less frequent since the half-life with DAC is up to 8 days. Therefore, the cycle for CJC 1295 with DAC calls for once weekly injections that result in an overall increase of secretion of GH. At this point, research does not show any significant advantage for one cycle over the other, so it is a matter of personal preference.

Mgf Muscle Gaining Peptides Hormone 2mg/Vial Mgf with Safe Delivery selina@ycgmp.com


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Product Name: MGF
Alias: Mechano Factor,  Ec
MF: C121H200N42O39
MW: 2868.16
Purity: 99%
Specification: 2mg/vial
Appearance: White Lyophilized Powder
Standard: USP
Certification: SGS
Method of Analysis: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below -18° C.

MGF (mechano Growth ) has been used by bodybuilders and athletes for a few years already. After resistance exercise,is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes.  It differs from "regular" mainly due to it's C-Terminal sequence.

How does Mechano Growth Factor work? - Muscle Growth!


When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene is released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue. The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary mechanism by which the body produces new muscle tissue.

Most users typically use a protocol of 100mcgs injected into each lagging muscle just after working it.